Key features and details | |
Cat. No. | MABL-2834 |
Name | Anti-Ribosomal P2-beta protein & beta-1 adrenergic receptor mAbs |
Clone No. | AFD- mAb 17.2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, WB, ELISA, FC |
Species Reactivity | Mouse (B1AR), Rat, T. cruzi (TcP2beta), Human |
Basic Information | |
Specificity | The antibody binds to the C-terminal region of T. cruzi ribosomal P2beta (epitope: EEEDDDMGFGLFD) and crossreacts with the human beta-1 adrenergic receptor. |
Alternative Name | TcP2beta; ADRB1 ; ADRB1R; B1AR; BETA1AR; RHR |
UniProt | Q26957 |
Immunogen | Recombinant TcP2-beta. |
Application Notes | This antibody binds to the carbodyl-terminal end of the ribosomal P2-beta protein of T. cruzi, which is part of the Trypanosome ribosome. The antibody cross-reacts with the human beta-1 adrenergic receptor, acting as an agonist. |
Antibody First Published | Mahler et al. A monoclonal antibody against the immunodominant epitope of the ribosomoal P2beta protein of Trypanosoma cuzi interacts with the human beta 1-adrenergic receptor. European Journal of Immunology 2001; 31(7):2210-2216 PMID:11449375 |
Note on publication | Describes the generation of murine antibodies against ribosomal P2beta of T. cruzi, showing evidence that it cross-reacts with human beta1-adrenergic receptor. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
