Anti-RANK-L mAbs

Cat. No.

MABL-2803

Name

Anti-RANK-L mAbs

Clone No.

AFD- WBP114_7.80

From

Recombinant Antibody

Isotype

Engineer antibody

Application

inhibition, SPR, ELISA

Species Reactivity

Human

Basic Information

Specificity

The antibody is specific for human-RANK-L. RANKL   is a tumor necrosis factor related protein that binds to, and activates, the   TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts   as the key cytokine that regulates osteoclast differentiation and activation   during normal bone remodeling and during disease

Alternative Name

CD254; TRANCE; RANKL; PAE30; ODF; OPGL;   Tumor necrosis factor ligand superfamily member 11; Osteoclast   differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear   factor kappa-B ligand; TNF-related activation-induced cytokine

UniProt

O14788

Immunogen

The original antibody was generated by immunizing Balb/c mice with human RankL protein.

Application Notes

The specificity of the original format of   the antibody to human RANKL was confirmed by ELISA analysis (EC50= 0.12 nM).   The antibody could block the RANKL binding to RANK (IC50 = 0.22 nM). The   original format of the antibody could inhibit the RANKL-inducible luciferase   activity (IC50 = 1.04 nM).The binding affinity of the original format of the   antibody to RANKL was measured by surface plasmon resonance (Kd= 60 pM)   (WO2019080909).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.