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Anti-RANK-L mAbs

简要描述:

The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease.

产品参数:

Cat. No.:MABL-2801

Species:Engineer

Species Reactivity:Human

Type:Recombinate

Application:Blocking, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2801

Name

Anti-RANK-L mAbs

Clone No.

AFD- RL

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, ELISA

Species Reactivity

Human

Basic Information


Specificity

The antibody is specific for human-RANK-L.   RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and  activates, the TNF receptor (TNFR)-related protein Receptor Activator of   NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast   differentiation and activation during normal bone remodeling and during   disease.

Alternative Name

CD254; TRANCE; RANKL; ODF; OPGL; Tumor   necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B   ligand; TNF-related activation-induced cytokine

UniProt

O14788

Immunogen

The original antibody was generated by   panning a Fab library against RANKL.

Application Notes

The origina antibody was capable of blocking the interactions between RANKL and its receptor RANK. The original antibody could potentially be used in an ELISA analysis (WO2015030701A1)

Antibody First   Published


Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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