Key features and details | |
Cat. No. | MABL-2768 |
Name | Anti-PSK mAbs |
Clone No. | AFD- 5G5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, IHC |
Species Reactivity | Trametes versicolor |
Basic Information | |
Specificity | The antibody is specific for the PSK protein and doesn't bind to other glucans having a similar structure. |
Alternative Name | Polysaccharide-K; Krestin; beta-glucan β-1->4 main chain with β-1->3 and β-1->6 side chains |
UniProt | |
Immunogen | The original antibody was generated by immunizing a mouse with the PSK antigen. |
Application Notes | ELISA was performed on PSK using this antibody (WO2012077737) (Hoshi et al, 2011; pmid:21249323). Tumor , liver and spleen tissues were used for immunohistochemistry using this antibody (Hoshi et al, 2011; pmid:21249323). This antibody was used for western blot on PSK protein (Hoshi et al, 2011; pmid:21249323). |
Antibody First Published | Hoshi et al. Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound. Oncol Rep. 2011 Apr;25(4):905-13. PMID:21249323 |
Note on publication | we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
