Key features and details | |
Cat. No. | MABL-2720 |
Name | Anti-PorA protein mAbs |
Clone No. | AFD- MN20B9.34 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional assay, WB, ELISA |
Species Reactivity | Neisseria meningitidis serogroup B |
Basic Information | |
Specificity | This antibody is specific for the P1.4 subtype antigen (HVVVNNKVATH) of serogroup B of Neisseria meningitidis. |
Alternative Name | PorA; Major outer membrane protein; outer membrane porin protein; PIA; Protein IA; Class 1 protein; serosubtype P1.4; serogroup B |
UniProt | Q51183; P0DH58 |
Immunogen | The original antibody was generated using outer membrane protein preparations from Neisseria meningitidis as immunogen. |
Application Notes | This antibody was used for the identification of PorA subtypes P1.4 using western blot. Antigenicity of the P1.4 epitope of PorA P1.7-2,4 in outer membrane vesicles and liposomes was tested by an inhibition ELISA (PMID； 14741154). This antibody is also reported to be highly bactericidal and was used as a positive control in a serum bactericidal assay (PMID: 14741154). |
Antibody First Published | Claassen et al. Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine. Vaccine. 1996 Jul;14(10):1001-8. PMID:8873395 |
Note on publication | Describes the generation of a vaccine which can induce bactericidal immune response in mice against five of the six wild type strains. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
