Key features and details | |
Cat. No. | MABL-2681 |
Name | Anti-PGE2 mAbs |
Clone No. | AFD- mAbPGE |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | |
Alternative Name | Prostaglandin E2 |
UniProt | |
Immunogen | Human PGE2. |
Application Notes | The antibody binds specifically to PGE2, a lipid compound synthesised from the oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2), and from the action of prostaglandin E synthase on prostaglandin H2. PGE2 is an important inflammatory mediator and homeostatic factor that acts on the receptors EP1, EP2 and EP3, which are all members of the family of G-protein coupled receptors (GPCRs). The neutralisation of PGE2 by the use of monoclonal antibodies provides an alternative to the use of NSAIDs in the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis. |
Antibody First Published | Shono F, Yokota K, Horie K, Yamamoto S, Yamashita K, Watanabe K, Miyazaki H. A heterologous enzyme immunoassay of prostaglandin E2 using a stable enzyme-labeled hapten mimic. Anal Biochem. 1988 Feb 1;168(2):284-91. PMID:3129960 |
Note on publication | Describes the development of an enzyme immunoassay for PGE2 utilising an anti- PGE2 antibody, in order to measure the amount of PGE2 present in human urine samples. |
COA Information (For reference only, actual COA shall prevail) | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |