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Anti-PCSK9 mAbs

简要描述:

​This antibody binds module 1 of the C-terminal domain (CTD) of PCSK9. It was reported to interact with amino acid residues R469, R496 and F515 of the human PCSK9. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease enzyme encoded by the PCSK9 gene in humans and it plays a role in regulation of circulating cholesterol. It is associated with autosomal dominant hypercholesterolemia, a state of elevated levels of LDL (low-density lipoprotein) cholesterol. Autosomal dominant hypercholesterolemia can result in severe implications such as stroke and coronary heart disease.

产品参数:

Cat. No.:MABL-2626

Species:Engineer

Species Reactivity:cynomolgus monkeys, Human

Type:Recombinate

Application:functional assay, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2626

Name

Anti-PCSK9 mAbs

Clone No.

AFD- mAb1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

functional assay, ELISA

Species Reactivity

cynomolgus monkeys, Human

Basic Information


Specificity

This antibody binds module 1 of the C-terminal domain (CTD) of PCSK9. It was reported to interact with amino acid   residues R469, R496 and F515 of the human PCSK9. Proprotein convertase   subtilisin/kexin type 9 (PCSK9) is a serine protease enzyme encoded by the PCSK9 gene in humans and it plays a role in regulation of circulating   cholesterol. It is associated with autosomal dominant hypercholesterolemia, a   state of elevated levels of LDL (low-density lipoprotein) cholesterol. Autosomal dominant hypercholesterolemia can result in severe implications such as stroke and coronary heart disease.

Alternative Name

NARC1; NARC-1; PC9; Proprotein convertase subtilisin/kexin type; Neural apoptosis-regulated convertase 1; Proprotein   convertase 9; Subtilisin/kexin-like protease PC9

UniProt

Q8NBP7

Immunogen


Application Notes

Proprotein convertase subtilisin/kexin type   9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL   receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering.   This antibody blocks access to an area bearing several naturally occurring   gain-of-function and loss-of-function mutations. This antibody does not   completely inhibit binding of PCSK9 to epidermal growth factor-like repeat A,   it partially reverses PCSK9-induced reduction of the LDLR and LDL cholesterol   uptake in a cellular assay. This antibody was also reported to be effective   in lowering serum levels of LDL cholesterol in cynomolgus monkeys in vivo   (PMID: 24252255).

Antibody First   Published

Schiele et al. An antibody against the   C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo. J Mol Biol.   2014 Feb 20;426(4):843-52. PMID:24252255

Note on publication

Describes the generation, structural and   biophysical characterization and in vitro and in vivo pharmacology of an   anti-PCSK9 antibody (mAb1).

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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