Key features and details | |
Cat. No. | MABL-2504 |
Name | Anti-Notch 1 mAbs |
Clone No. | AFD- E6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, IHC |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | An engineered ScFv fragment antibody that binds to both mouse mNRR1 and human hNRR1 but not NRR2. |
Alternative Name | Tan1; Notch1; Mis6; N1; lin-12; NOTCH1; TAN1; hN1 |
UniProt | P46531 (human); Q01705 (mouse) |
Immunogen | This antibody was selected against a fusion protein consisting of EGF domains 1–12 of murine Notch1 fused to a human Fc domain and binds to the NRR of mouse Notch1. |
Application Notes | |
Antibody First Published | Falk R, Falk A, Dyson MR, Melidoni AN, Parthiban K, Young JL, Roake W, McCafferty J. Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods. 2012 Sep;58(1):69-78. PMID:22842086 |
Note on publication | Describes the generation of Notch receptor blocking antibodies using Phage Display. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
