Key features and details | |
Cat. No. | MABL-2487 |
Name | Anti-Nkp46 mAbs |
Clone No. | AFD- 29A1.4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | activation, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody is specific for mouse NKp46-Fc. |
Alternative Name | CD335; NK-p46; NKp46; mNKp46; mAR-1; Activating receptor 1; Lymphocyte antigen 94; Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1 |
UniProt | Q8C567 |
Immunogen | The original antibody was generated by immunizing rats with mouse NKp46-Fc recombinant protein. |
Application Notes | The original format of this antibody was used in an FC analysis to detect NKp46 expression on NK cells and to activate NK in an NK cell stimulation assay (Walzer et al., 2007; PMID: 17360655). This antibody was used as a component of bispecific NKCEs (Natural Killer Cell Engagers) to redirect the cytotoxic activity of NK cells towards human CD20-expressing tumor cells in a transplantable xenogeneic in vivo solid tumor model (Gauthier et al., 2019; PMID: 31155232). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
