Key features and details | |
Cat. No. | MABL-2486 |
Name | Anti-NKG2D mAbs |
Clone No. | AFD- ON72 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | agonist, ELISA, FC |
Species Reactivity | cynomolgous monkey, Human, Rhesus Monkey |
Basic Information | |
Specificity | This antibody recognizes human, cynomolgous monkey and rhesus monkey NKG2D, but does not cross react with mouse rat, dog or pig NKG2D. Natural killer (NK) cells serve as key innate effectors and their activity has been considered a prognostic biomarker in diverse human diseases. NKG2d functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. |
Alternative Name | KLRK1; CD314; NKG2-D type II integral membrane protein; NK cell receptor D; Killer cell lectin-like receptor subfamily K member 1; NKG2-D-activating NK receptor; KYK2; KYK- 2.0 |
UniProt | P26718 |
Immunogen | The original antibody was generated by grafting of CDRs from mouse parental clone onto human framework regions. |
Application Notes | This antibody is capable of recognizing NKG2D in an ELISA. This antibody was successful in staining and identification NKG2D expressed on PBMCs isolated from human, cynomolgous monkey and rhesus monkey in a flow cytometric assay (US7879985). This antibody was used to study the distribution of NKG2D on human peripheral blood cells by flow cytometry (PMID: 15048706). The immobilized version of this antibody was reported to show agonistic activity (US7879985). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
