Anti-Membrane type 1 metalloprotease mAbs

Cat. No.

MABL-2342

Name

Anti-Membrane type 1 metalloprotease mAbs

Clone No.

AFD- LEM-2/15

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody binds to residues 218-233 of   the V-B loop of MT1-MMP with a Kd of 2.32E10-9M.

Alternative Name

MT1-MMP

UniProt

Immunogen

The cyclic peptide possessing the sequence   of residues 218-233 of the V-B-loop of MT1-MMP.

Application Notes

This antibody binds to residues 218-233 of the   V-B loop of MT1-MMP which is a mediator of cell migration and is frequently involved in malignancy of tumours by promoting metastasis.The antibody acts   as a non-competitive inhibitor of the receptor.

Antibody First   Published

Udi et al. 2015 Inhibition mechanisms of   membrane metalloprotease by an exosite swiveling conformational antibody.   Structure 2015; 23: 104-115 PMID:25482542

Note on publication

Describes the crystal structures of the   LEM-2/15 bound to MT1-MMP.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.