Key features and details | |
Cat. No. | MABL-2292 |
Name | Anti-Lysophosphatidic acid mAbs |
Clone No. | AFD- B3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | This antibody binds lysophosphatidic acid (LPA), which is a bioactive lipid mediating multiple cellular responses including proliferation, differentiation, angiogenesis, motility, and protection from apoptosis in a variety of cell types. LPA is involved in the establishment and progression of cancer by providing a pro-growth tumor microenvironment and promoting angiogenesis. In addition, LPA has been implicated in neurotrauma, fibrosis, ocular diseases such as macular degeneration, and pain-related disorders. |
Alternative Name | LPA; Lpathomab; LT3000 |
UniProt | |
Immunogen | The original antibody was generated by immunizing mice with the thio-LPA-KLH hapten. |
Application Notes | The binding characterization of this antibody for different isoforms of LPA was done using ELISA.The original antibody binds LPA with a very high binding affinity of Kd= 1.4 pM. This antibody is capable of recognizing all the isoforms of LPS |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
