Key features and details | |
Cat. No. | MABL-2074 |
Name | Anti-IL-3Ra mAbs |
Clone No. | AFD- 57A07 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FACS, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for the alpha subunit of IL-3R |
Alternative Name | CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; interleukin 3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha |
UniProt | P26951 |
Immunogen | |
Application Notes | The binding of the original version of this antibody (VHH) to IL3-Ra-expressing viral lipoparticles was characterized in an ELISA (KD 0.783 nM). In a FACS binding assay, this antibody exhibited an EC50 of 0.66 nM, 1.3 nM, and 0.24 nM for MOLM-13, THP-1, and HEK-IL-R3a, respectively, and an IC50 of 1.20 nM in competition against clone 7G3. In its bi-specific constructions with clones 14D09 and 281F12, it served as an anchor (US20220242958). |
Antibody First Published | |
Note on publication | The original publication describes the construction and characterization of various bi- specific antibodies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
