Key features and details | |
Cat. No. | MABL-2061 |
Name | Anti-IL-2 mAbs |
Clone No. | AFD- S4B6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, SPR, ELISA |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody binds specifically to mouse IL-2. |
Alternative Name | Interleukin-2 |
UniProt | P04351 |
Immunogen | Interleukin-2. |
Application Notes | This antibody binds to Interleukin-2, a protein produced by T-cells in response to antigenic or mitogenic stimulation. It triggers T-cell proliferation and can stimulate B-cells, monocytes, natural killer cells and glioma cells. The antibody blocks the Il-2:IL-2R-beta interaction. |
Antibody First Published | Spangler et al. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity 2015; 42(5):815-8125 PMID:25992858 |
Note on publication | Describes the generation of two monoclonals against mouse IL-2 and subsequent blocking studies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
