Key features and details | |
Cat. No. | MABL-1903 |
Name | Anti-Human Glucagon Receptor mAbs |
Clone No. | AFD- hGR-2 F6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody binds to the human glucagon receptor. |
Alternative Name | hGR |
UniProt | P47871 |
Immunogen | Recombinant human glucagon receptor. |
Application Notes | This antibody binds to the human glucaon receptor, a GPCR that is activated by glucagon and stimulates adenylate cyclase. The receptor is involved in glucose homeostasis and regulats glucose production in the liver. The antibody acts as a competitive antagonist. |
Antibody First Published | Wight et al. Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor. Acta Crystallography Section D Biological Crystallography 2000; 56(5)573-580 PMID:10771426 |
Note on publication | Describes the crystallisation of mAb hGR-2 F6 with the glucagon receptor and subsequent binding- and inhibition studies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
