Key features and details | |
Cat. No. | MABL-909 |
Name | Anti-CD38 mAbs |
Clone No. | AFD-MU1053 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallography, therapeutic, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | MU1053 binds an epitope close to the C-terminal region of CD38. The residues composing this epitope are: N120, K121, F135, Q139, M142, D202, V203, H205, Q236, T237, E239, W241, Q272, S274, K276, I278, F284, C287, V288, P291, E292, S294, C296. |
Alternative Name | Cluster of Differentiation 38; ADP-Ribosyl Cyclase 1; ADPRC1; ADPRC 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleoti |
UniProt | P28907 |
Immunogen | The C-terminal domain of human CD38 (residue 45–300) was expressed and produced in a yeast expression system. The purified recombinant protein was used as an antigen to immunize llamas. Phage display technology was used to obtain positive clones against CD38. |
Application Notes | The nanobody MU1053 has been crystallised with CD38, and has been used to target molecules to CD38. Tagging the nanobody with fluorescent proteins allows the quantification of CD38 expression by flow cytometry, which can be used to identify malignant multiple myeloma cells, which have higher CD38 expression. Further, a form of MU1053 conjugated to a toxin has been developed as a potential therapeutic agent to selectively kill CD38+ cells. |
Antibody First Published | Li et al. Immuno-targeting the multifunctional CD38 using nanobody. Sci Rep. 2016 Jun 2;6:27057 PMID:27251575 |
Note on publication | Describes increased CD38 expression in malignant cells and its potential as a drug target for cancer therapy. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
