Key features and details | |
Cat. No. | MABL-908 |
Name | Anti-CD38 mAbs |
Clone No. | AFD- HB7 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to an epitope between amino acids 273-285 of human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone AT13/5 (Ab00289) (Ellis 1995). |
Alternative Name | ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; EC 3.2.2.5; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; p45; NAD(+) nucleosidase |
UniProt | P28907 |
Immunogen | Viable cells (1 x 10E7) of the human cell line, BJAB (Human Burkitt lymphoma B cell line), which was were injected intraperitoneally into 8-week-old BALB/c mice. |
Application Notes | A customer reports successfully using this antibody (coupled to magnetic beads) for isolation of plasma cells from the intestinal lamina propria. |
Antibody First Published | Tedder TF, Clement LT, Cooper MD. Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation. Tissue Antigens. 1984 Sep;24(3):140-9. PMID:6440308 |
Note on publication | Describes the making of the antibody, shows it recognised HB-7 antigen protein using flow cytometry and immunoblotting. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
