Cat. No.
MABL-1168
Application
IP, stimulatory, FC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
RL388
From
Recombinant Antibody
Specificity
This antibody recognises murine CD98, a heterodimeric cell surface glycoprotein.
Alternative Names
4F2hc; 4F2 cell-surface antigen heavy chain; Solute carrier family 3 member 2; RL-388; 4F2; SLC3A2;
UniProt
P10852
Immunogen
This antibody was raised by immunising rats with an IL 2-producing subline of the mouse T lymphoma EL4.
Application Notes
This antibody has been used in immunoprecipitation analysis to characterise the CD98 antigen (Luscher et al, 1985) and flow cytometric analysis of CD98 expression by γδ T cells (Cao et al, 2016). This antibody has been shown to stimulate IL-2 secretion by a T cell lymphoma EL4 subline (EL4-6.1) in the presence of IL-1 (MacDonald et al, 1985). This antibody did not exert stimulatory effects on the parental EL4 line nor a series of ovalbumin-specific T-T hybrids (MacDonald et al, 1985).
Antibody First Published
MacDonald et al. Cell surface glycoproteins involved in the stimulation of interleukin 1-dependent interleukin 2 production by a subline of EL4 thymoma cells. I. Functional characterization by monoclonal antibodies. J. Immunol. December 1, 1985, 135 (6) 3944-3950 PMID:2415592
Note on publication
Describes the original generation of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
