Cat. No.
MABL-1124
Application
Block, FC, IF, IHC-Fr
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
YTS 105.18
From
Recombinant Antibody
Specificity
Recognizes a non polymorphic epitope on the mouse CD8 alpha chain. This antibody has been reported to block MHC I dependent T cell responses in vitro and in vivo.
Alternative Names
Lyt-2; CD8A Antibody; CD8a molecule Antibody; CD8a antigen Antibody; OKT8 T-cell antigen Antibody; Leu2 T-lymphocyte antigen Antibody; T8 T-cell antigen Antibody; T cell co- receptor Antibody; p32 Antibody; CD8 Antibody; Leu2 Antibody; T-cell antigen Leu2
UniProt
P01731
Immunogen
Ly-2-transfected mouse L cells.
Application Notes
This antibody can be used to stain for murine CD8 and can be used to block interaction with CD8.
Antibody First Published
Qin SX, Wise M, Cobbold SP, Leong L, Kong YC, Parnes JR, Waldmann H. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol. 1990 Dec;20(12):2737-45. PMID:1702726
Note on publication
Describes the generation of this antibodies and its characterization, including its funtion in suppressing skin graft rejection.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
