Cat. No.
MABL-906
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AT13/5
From
Recombinant Antibody
Specificity
Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7 (Ab00128) (Ellis 1995) which has been shon to bind to an epitope between amino acids 273-285).
Alternative Names
ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; EC 3.2.2.5; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; p45; NAD(+) nucleosidase
UniProt
P28907
Immunogen
Namalwa cells emulsified in CFA.
Application Notes
The antibody binds to CD38, a glycoportein on the surface of various immune cells that catalyzes the hydrolysis of cyclic ADP-ribose to NAD+ and ADP-ribose.
Antibody First Published
Ellis et al Engineered anti-CD38 monoclonal antibdies for immunotherapy of multiple myeloma. Journal of Immunology PMID:7608568
Note on publication
Describes the generation of murine monoclonal antibodies against CD38 and its potential use in therapy of multiple myeloma.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
