Cat. No.
MABL-901
Application
FC, IF, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
IPO-24 (ZC37-24)
From
Recombinant Antibody
Specificity
This antibody recognizes CD37, which is a cell surface protein, present mostly on mature B cells and B cell malignancies.
Alternative Names
Tetraspanin-26; Leukocyte antigen CD37; tetraspanin; Tspan-26; Gp52- 40
UniProt
P11049
Immunogen
This antibody was raised by immunizing mice with spleen cells of a patient with hairy cell leukemia.
Application Notes
This antibody is recommended for the analysis and detection of B cells and their malignancies as CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies, such as B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin's lymphoma (B-NHL). Consequently, this antibody might be useful for the treatment of B cell malignancies and autoimmune and inflammatory diseases that involve B cells in their pathology. Finally, IPO-24 antibody, might be used to identify CD37 via various techniques. For instance, it was used to evaluate CD37 expression in mantle cell lymphoma samples via immunohistochemistry (Leshchenko et al., 2010).
Antibody First Published
Moldenhauer CD37. J Biol Regul Homeost Agents. 2000 Oct-Dec;14(4):281-3. PMID:11215818
Note on publication
This article describes the characterization of the IPO-24 antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
