Cat. No.
MABL-733
Application
in vivo, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
hz1022C3
From
Recombinant Antibody
Specificity
This antibody is specific for the membrane proximal domain of ADAM17.
Alternative Names
CSVP; TACE; ADAM17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; Disintegrin and metalloproteinase domain-containing protein 17
UniProt
P78536
Immunogen
The original antibody was raised by immunzing a BALB/c mouse with human ADAM17 recombinant protein and then humanizing the resulting antibody.
Application Notes
The original antibody was used for an ELISA on human ADAM17 to determine its binding affinity. The antibody was used for flow cytometry on A172 human tumour cells to confirm that it could bind to cellular ADAM17. This antibody was used in vivo on mice in which A431 tumors were established, treatment with the antibody showed significant tumor inhibition and regression was observed in all animals, it achieved complete regression in two mice (US20180057601A1).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
