Cat. No.
MABL-687
Application
IF, IHC-Fr
Isotype
Engineer antibody
Species Reactivity
Mouse and Human
Clone No.
5C6 (recombinant version)
From
Recombinant Antibody
Specificity
This antibody specifically recognize CD11b, also known as the integrin alpha M chain (MAC-1), which is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages.
Alternative Names
integrin alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
UniProt
P11215
Immunogen
Fusion of spleen cells from AO rats immunised with Thioglycollate-elicted muine peritoneal macrophages (TPM) and the Y3 rat myeloma line.
Application Notes
Antibody First Published
Rosen H, Gordon S. Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo and can thereby potentiate infection. J Exp Med. 1987 Dec 1;166(6):1685-701. PMID:2445894
Note on publication
Describes the isolation of 5C6 and analysis of Mg2+-dependent macrophage adhesion.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
