Cat. No.
MABL-672
Application
Blocking, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
B-K9 (C106-K9)
From
Recombinant Antibody
Specificity
B-K9 antibody recognizes CD106 (VCAM1). CD106 is a member of the Ig superfamily. It is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis.
Alternative Names
VCAM1; Vascular cell adhesion protein 1; V-CAM 1; INCAM-100
UniProt
P19320
Immunogen
This antibody was raised by immunizing Balb/c mice against activated human umbilical vein endothelial cells (HUVEC).
Application Notes
B-K9 antibody inhibits the binding of leukocytes to VCAM-1 on stimulated endothelial cells, and thus it blocks the ability of white blood cells to attach themselves to the activated epithelium during, for instance, inflammation. Consequently, this antibody might be used in research where leukocytes adhesion-blocking is required (Uotila et al., 2014; Wagner et al. 2011).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
