Cat. No.
MABL-382
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Immu31
From
Recombinant Antibody
Specificity
This antibody is specific for human alpha-fetoprotein.
Alternative Names
AFP; Alpha-1-fetoprotein; Alpha-fetoglobulin; α-fetoprotein
UniProt
P02771
Immunogen
The original antibody was generated by immunizing a mouse (unspecified) with human alphafetoprotein.
Application Notes
The specificity of the original version of this antibody (mouse IgG2a) was validated via ELISA. Chimeric and humanized versions of this antibody were subsequently developed and compared (Qu et al., 1999; PMID： 10541349) (US8017736B2).
Antibody First Published
Qu et al., Humanization of Immu31, an alpha-fetoprotein-specific antibody.Clin Cancer Res. 1999 Oct;5(10 Suppl) 3095s-3100s. PMID：10541349
Note on publication
The original publication details the humanization process of Immu31, a murine monoclonal antibody specific to the tumor marker alpha-fetoprotein (AFP), to enhance its suitability for diagnostic and therapeutic applications in humans by preserving its binding affinity while using human antibody frameworks.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
