Key features and details | |
Cat. No. | MABL-755 |
Name | Anti-CD19 mAbs |
Clone No. | AFD- 1D3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | The antibody is specific for mouse CD19. |
Alternative Name | B-lymphocyte antigen CD19; Differentiation antigen CD19 |
UniProt | P25918 |
Immunogen | |
Application Notes | The scFv fragment of the antibody was employed in the generation of a chimeric antigen receptor (CAR) which bound to CD19. Mice were administered mouse CAR-expressing cells or control cells. Anti-muCD19 CAR-T mice exhibited elevated serum IL-6 levels on day 2 after CAR-T administration, with a decrease at day 5, compared to control mice that exhibited very low or no increase in serum IL-6 levels. A20 tumor bearing mice were administered CPA and anti -mouse CD 19 CAR-T cells and evaluated for various parameters. Animals treated with CPA and anti-mouse CD 19 CAR-T cells were observed to have elevated levels of serum cytokines, as compared to controls (EP3644721A1). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
