Key features and details | |
Cat. No. | MABL-258 |
Name | Anti-Cocaine mAbs |
Clone No. | AFD-7A1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | This antibody binds to cocaine, a strong stimulant used clinically as a local analgesic and vasoconstrictor and illegally as a recreational drug. |
Alternative Name | Benzoylmethylecgonine; coca; coke; crack; ChEBI: 27958 |
UniProt | |
Immunogen | The original antibody was generated by immunizing mice with a phosphonate mono-ester transition state analog (TSA) of cocaine coupled through a covalent linkage to the carrier protein keyhole limpet hemocyanin (KLH). |
Application Notes | This antibody catalyzes the hydrolysis of cocaine to produce nonpsychoactive metabolites ecgonine methyl ester and benzoic acid. |
Antibody First Published | Zhu et al. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure. 2006 Feb;14(2):205-16. PMID:16472740 |
Note on publication | The paper describes the significant structural changes that occur during the hydrolysis of cocaine to form nonpsychoactive metabolites. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
