Key features and details | |
Cat. No. | MABL-206 |
Name | Anti-Kir2.2 K+ mAbs |
Clone No. | AFD-N124B/38R |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB |
Species Reactivity | Rat |
Basic Information | |
Specificity | This antibody is specific for Kir2.2. It shows no cross-reactivity against Kir2.1 or Kir2.3. Kir2.2 is an inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. |
Alternative Name | ATP-sensitive inward rectifier potassium channel 12; Kcnj12; Inward rectifier K(+) channel Kir2.2; IRK-2; Potassium channel, inwardly rectifying subfamily J member 12; N124B/38 |
UniProt | P52188 |
Immunogen | This antibody was raised against a synthetic peptide of amino acids 390-410 of rat Kir2.2. |
Application Notes | FDB and IO muscles of mice were immunoblotted with this antibody (DiFranco et al, 2015; PMID:25545278). |
Antibody First Published | DiFranco et al. Inward rectifier potassium currents in mammalian skeletal muscle fibres J Physiol. 2015 Mar 1;593(5):1213-38. PMID:25545278 |
Note on publication | It was found that Kir2.1 and Kir2.2 channels were targeted to both the surface and the transverse tubular system membrane (TTS) compartments and that both isoforms can be overexpressed up to 3-fold 2 weeks after transfection. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
