Anti-KCNU1/Slo3 maxi-K+ channel mAbs

Cat. No.

MABL-112

Name

Anti-KCNU1/Slo3 maxi-K+ channel  mAbs

Clone No.

AFD-N2/16

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Species Reactivity

Mouse

Basic Information

Specificity

This antibody is specific for the Kcnu1 protein.   Kcnu1 is a testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+.

Alternative Name

 N2/16R; N2/16; Potassium channel subfamily U   member 1; Calcium- activated potassium channel subunit alpha-3;   Calcium-activated potassium channel, subfamily M subunit alpha-3;   Pore-forming subunit of the sperm-specific alkalization activated K(+)   current; KSper; Slowpoke homolog 3; mSlo3; pH-sensitive maxi potassium   channel

UniProt

O54982

Immunogen

This antibody was raised by immunising   BALB/c mice with a fusion protein amino acids 1052- 1121 of mouse Slo3.

Application Notes

This antibody was used to preform a   western blot on mouse oocytes and the testis of SLo3 knockout mice (Yang et   al, 2011; PMID:22084117) (Santi et al, 2010;PMID:20138882).  Immunopercipitation on mouse oocytes has been preformed with this antibody   (Yang et al, 2011; PMID:22084117).

Antibody First Published

Santi et al. The SLO3 sperm-specific potassium channel plays a vital role in male fertility FEBS Lett. 2010 Mar   5;584(5):1041-6. PMID:20138882

Note on publication

This article describes the knockout   of the SLo3 gene and the subsequent results on mouse fertility

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.