Cat. No.
MABL-3691
Application
Cytotoxicity Assay, IHC-P, in vivo, WB, ELISA, FC, IHC-Fr
Isotype
Engineer antibody
Species Reactivity
Human, Rhesus Monkey, Cynomolgus Monkey
Clone No.
Alemtuzumab (Campath-1H)
From
Recombinant Antibody
Specificity
Human CD52 antigen, also known as CAMPATH-1. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable.
Alternative Names
CDW52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; YTH66.9HL
UniProt
P31358
Immunogen
Human lymphocytes.
Application Notes
Antibody First Published
Riechmann L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. Nature. 1988 Mar 24;332(6162):323-7. PMID:3127726
Note on publication
Describes the reshaping of the rat IgG2b antibody to human IgG1 and shows that it recognises human CD52 antigen.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
