Cat. No.
MABL-3349
Application
crystallization, Block, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AFD-huMaE11 (Omalizumab)
From
Recombinant Antibody
Specificity
This antibody binds to circulating human IgE antibody, but not to cell-bound IgE. It binds in proximity of the binding site of the high-affinity IgE receptor Fc epsilon RI.
Alternative Names
epsilon chain; Ig epsilon chain C region; immunoglobulin E
UniProt
P01854
Immunogen
Human IgE protein.
Application Notes
This antibody is the humanized version of original mouse antibody MAE11. This antibody binds to circulating IgE, thereby inhibiting IgE binding to mast-cells. It does not bind to cell-bound IgE and does not provoke histamine release from mast-cells sensitised by IgE. As a human IgG1, marketed as Xolair™, it is used therapeutically to treat asthma and allergies.
Antibody First Published
Presta et al. Humanization of an antibody directed against IgE. J Immunol. 1993 Sep 1;151(5):2623-32. PMID:8360482
Note on publication
Describes the role of the house dust mite allergen Der p 7 in allergy, and the generation of monoclonal antibodies that target Der p 7.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
