Cat. No.
MABL-3348
Application
Block, ELISA
Isotype
Engineer antibody
Species Reactivity
House Dust Mite
Clone No.
AFD-WH9
From
Recombinant Antibody
Specificity
This antibody binds to the house dust mite allergen Der p 7 and competes with a subset of naturally occurring IgE.
Alternative Names
Mite allergen Der p 7; Allergen Der p VII; Major mite fecal allergen Der p 1; Dermatophagoides farinae allergen 1; Dermatophagoides pteronyssinus allergen 1
UniProt
P49273
Immunogen
Recombinant Der p 7.
Application Notes
The antibody binds specifically to Der p 7, a house dust mite allergen which plays an important role in inflammatory and hypersensitive reactions. The antibody WH9 binds to an epitope which is overlapping with that of IgE, thereby inhibiting its binding by up to 60%. By preventing mast cell degranulation, the antibody can be useful in the development of hypoallergenic vaccines.
Antibody First Published
Shen et al. Characterization of the house dust mite allergen Der p 7 by monoclonal antibodies. Clin Exp Allergy. 1995 May;25(5):416-22. PMID:7553244
Note on publication
Describes the generation and characterization of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
