Cat. No.
MABL-3586
Application
crystallization, NTRL, ELISA
Isotype
Engineer antibody
Species Reactivity
MERS-CoV
Clone No.
4c2
From
Recombinant Antibody
Specificity
This antibody binds MERS-CoV spike protein at an epitope overlapping with the receptor- binding domain (MERS-RBD).
Alternative Names
MERS-RBD; Middle East respiratory syndrome coronavirus spike
UniProt
Immunogen
Recombinant spike receptor-binding domain of MERS-CoV prepared from insect High5 cells.
Application Notes
This antibody binds to MERS-RBD and blocks virus entry in vitro with high efficacy by both steric hindrance and interface-residue competition.
Antibody First Published
Li et al. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Cell Research 25, 1237-1249 PMID:26391698
Note on publication
Describes the generation as well as functional and structural characterization of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
