Cat. No.
MABL-3979
Application
ICC, IHC-FFPE, WB, ELISA, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
KGH-R1
From
Recombinant Antibody
Specificity
This antibody recognizes human wild-type and mutant H-, K-, and N-Ras proteins. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein plays an important role in many signal transduction pathways and regulation of cell proliferation. Somatic ras mutations are highly observed in leukemias, colorectal cancer, pancreatic cancer and lung cancer.
Alternative Names
p21; p21 ras protein; Ras; pan ras; K-Ras; GTPase Kras; KRAS2; RASK2; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; ras p21 protein; p21 ras; GTPase Hras; HRAS; H-RAS; HRAS; HRAS1; GTPase HRas; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras; N-RAS; NRAS; HRAS1; GTPase NRas; Transforming protein N-Ras
UniProt
P01116; P01112; P01111
Immunogen
Synthetic peptide corresponding to aa 371-380 of human p53.
Application Notes
Antibody First Published
Harlow E, Crawford LV, Pim DC, Williamson NM. Monoclonal antibodies specific for simian Virus 40 tumor antigens. J Virol. 1981 Sep;39(3):861-9. PMID:6169844
Note on publication
Describes the production and subsequent characterisation of anti-p53 monoclonal antibody clones.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
