Cat. No.
MABL-3939
Application
functional assay, inhibit, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MBM-14
From
Recombinant Antibody
Specificity
This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF- β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF- 15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Alternative Names
MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1; Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
UniProt
Q99988
Immunogen
The original antibody was generated by immunizing 6-week-old healthy New Zealand female white rabbits subcutaneously with human glypican-1.
Application Notes
The binding characterization of this antibody to human glypican-1 was determined using ELISA. The binding of this antibody to human glypican-1 expressed on the surface of human breast cancer cell line MDA-MB-231 was determined using flow cytometry (CN112300283).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
