Key features and details | |
Cat. No. | MABL-542 |
Name | Anti-BR3 mAbs |
Clone No. | AFD- V3-46s |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, ELISA |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | This antibody is specific for the BR3 protein. |
Alternative Name | Tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; B- cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268 |
UniProt | Q96RJ3 |
Immunogen | The original antibody was generated from a synthetic antibody library that was built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions. |
Application Notes | This antibody was used for ELISA on mBR3-ECD and hBR3-ECD (US20080181888). This antibody blocks BAFF-BR3 binding (US20080181888). The Fab version of this antibody bound mouse BR3- ECD and human BR3-ECD with an affinity of 1nM and 0.6nM respectively. Humanized V3-46s antibody also blocked BAFF binding to BR3 on BJAB cells and bound BR3 on BJAB cells. This antibody was used as a template to make homolog shotgun libraries (US20080181888). |
Antibody First Published | Ambrose et al. Polypeptides That Bind Br3 and Uses Thereof. US20080181888 |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
