Key features and details | |
Cat. No. | MABL-493 |
Name | Anti-Bcl-3 mAbs |
Clone No. | AFD- ham150-3.5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, FC |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | The antibody is specific for BCL-3. B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. |
Alternative Name | B-cell lymphoma 3 protein homolog |
UniProt | Q9Z2F6 |
Immunogen | The original antibody was generated from a hamster immunized with mouse BCL-3. |
Application Notes | The specificity of the original format of the antibody for mBcl-3 was confirmed by ELISA analysis. The antibody detected mBcl-3 and human Bcl-3 by western blot (Bassetti et al., 2009; PMID： 19208752). |
Antibody First Published | Bassetti et al. Transgenic Bcl-3 slows T cell proliferation. Int Immunol. 2009 Apr; 21(4)： 339–348. PMID：19208752 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
