Key features and details | |
Cat. No. | MABL-3132 |
Name | Anti-Transglutaminase 2 mAbs |
Clone No. | AFD- 679-14-E06 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody binds to the N-terminal region of TG2 with a Kd of 55 nM. |
Alternative Name | TG2; Protein-Glutamine gamma-Glutamyltransferase 2 |
UniProt | P21980 |
Immunogen | Autoantigen TG2. |
Application Notes | This antibody binds to human Transglutaminase 2, an enzyme that catalyzes the isopeptide bond formation between an amine group and an acyl group at the end of the side chain of a glutamine. Anti-TG2 antibody are found in celiac disease and high levels of transglutaminase are found in Huntington's and Parkinson's. |
Antibody First Published | Chen et al. Structural basis for antigen recognition by transglutaminase 2- specific autoantibodies in celiac disease. Journal of Biological Chemistry 2015; Manuscript M115.669895 PMID:26160175 |
Note on publication | Describes autoantibodies against TG2 and crystallisation as well as molecualar dynamic simulations. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
