Anti-Tissue factor mAbs

Cat. No.

MABL-3093

Name

Anti-Tissue factor mAbs

Clone No.

AFD- 5G9

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, Block, ELISA

Species Reactivity

Human

Basic Information

Specificity

Alternative Name

TF; platelet tissue factor; factor III;   thromboplastin; CD142

UniProt

P13726

Immunogen

Human TF.

Application Notes

The antibody binds specifically to TF, a hemostatic protein which is involved in the extrinsic pathway of coagulation.   TF is receptor for circulating serine protease factor VIIa, activating the   catalytic VIIa protease domain. The complex formed functions to activate the   zymogen factor X into activated factor Xa, which then catalyses the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts   to stop bleeding. The monoclonal antibody 5G9 acts as a competitive inhibitor   of factor X, thereby inhibiting its activation by the TF.VIIa complex and the   formation of a clot.

Antibody First   Published

Ruf W, Edgington TS. An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant  in plasma. Thromb Haemost. 1991 Nov 1;66(5):529-33. PMID:1803616

Note on publication

Describes the production of a murine   monoclonal antibody directed against TF, and inhibits the complex of TF which   Factor VIIa, thereby acting as an anticoagulant in plasma.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.