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Anti-RNase A mAbs

简要描述:

This antibody binds bovine RNase A. RNase A is an endonuclease enzyme that catalyzes the cleavage of RNA on the 3‘ side of pyrimidine nucleotides. It acts on single-stranded and double-stranded RNA.

产品参数:

Cat. No.:MABL-2841

Species:Engineer

Species Reactivity:calf

Type:Recombinate

Application:ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2841

Name

Anti-RNase A mAbs

Clone No.

AFD- cAb-RN05

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ELISA

Species Reactivity

calf

Basic Information


Specificity

This antibody binds bovine RNase A. RNase A is   an endonuclease enzyme that catalyzes the cleavage of RNA on the 3' side of   pyrimidine nucleotides. It acts on single-stranded and double-stranded RNA.

Alternative Name

Ribonuclease pancreatic; RNASE1; RNase 1; RNaseA; RNS1 RN05

UniProt

P61823

Immunogen

The original antibody was generated by   immunizing a dromedary (Camelus dromedarius) with bovine RNase A. The   affinity matured version of this antibody was generated using synthetic   combinatorial libraries.

Application Notes

This antibody binds bovine RNase with an   affinity in the picomolar range. This affinity matured version of VHH   antibody cAb-RN05 binds bovine RNase with an affinity of Kd= 180 pM (PMID:   17888451). 5′–3′ cUMP that binds into the active site of RNase A does not   compete with cAb-RN05 for binding to RNase A in an ELISA (PMID: 10196124).

Antibody First   Published

Koide et al. Exploring the capacity of   minimalist protein interfaces: interface energetics and affinity maturation   to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol.   2007 Nov 2;373(4):941-53. PMID:17888451

Note on publication

Describes the affinity maturation of a VVH   antibody against bovine RNase.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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