Anti-Progesterone mAbs

Cat. No.

MABL-2751

Name

Anti-Progesterone mAbs

Clone No.

AFD- DB3

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block, ELISA, IHC

Species Reactivity

Species independent

Basic Information

Specificity

The antibody binds progesterone with an   affinity (Kd) of 1 nM.

Alternative Name

P4; D

UniProt

Immunogen

11-a-hydroxyprogesterone-11-hemisuccinyl-bovine   serum albumin (BSA) conjugate.

Application Notes

The antibody binds specifically to   progesterone, a steroid female sex hormone produced by the corpus luteum in   the ovaries, and then by the placenta during pregnancy. The hormone is necessary for maintenance of pregnancy as it prevents the breakdown of the   endometrium. Monoclonal antibodies against progesterone can be useful to   increase the understanding of the role of the hormone in the female reproductive system, and may be potentially used as an immunological prevention of pregnancy. Studies have shown that the injection of DB3 in female mice had   anti-fertility effects. It is thought that DB3 may inhibit pregnancy by   binding to a progesterone transport protein, thereby preventing the uptake of   progesterone by epithelial cells of the uterine tissue.

Antibody First   Published

Stura EA, Arevalo JH, Feinstein A, Heap RB,   Taussig MJ, Wilson IA. Analysis of an anti-progesterone antibody: variable crystal morphology of the Fab' and steroid-Fab' complexes. Immunology. 1987   Dec;62(4):511-21. PMID:3123368

Note on publication

Describes the production of an   anti-progesterone monoclonal antibody DB3, which can be used to terminate   pregnancy shortly after fertilization, and for hormone immunoassay.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.