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Anti-PI-LPS mAbs

简要描述:

The antibody recognizes a PI specific epitope on PI-LPS. The antibody does not cross react with PII-LPS.

产品参数:

Cat. No.:MABL-2695

Species:Engineer

Species Reactivity:​C. burnetii

Type:Recombinate

Application:in vitro, in vivo, WB, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2695

Name

Anti-PI-LPS mAbs

Clone No.

AFD-1E 4

From

Recombinant Antibody

Isotype

Engineer antibody

Application

in vitro, in vivo, WB, ELISA

Species Reactivity

C. burnetii

Basic Information


Specificity

The antibody recognizes a PI specific   epitope on PI-LPS. The antibody does not cross react with PII-LPS.

Alternative Name

phase I lipopolysaccharide; LPS phase I; C.   burnetii PI-LPS; C. burnetii phase I lipopolysaccharide

UniProt


Immunogen

The original antibody was generated by   immunizing BALB/c mice with formalin-inactivated C. burnetii Nine Mile PI   antigen.

Application Notes

The specificity of the antibody (IgG2a) for   PI-LPS was confirmed by ELISA analysis. The antibody detected PI-LPS by   western blot analysis. The antibody was able to inhibit C. burnetii infection   in vivo in a dose-dependent manner (Peng et al., 2012; PMID: 23053512). The   original antibody could confer protection against C. burnetii aerosol   infection. The Fab fragment, the scFv fragment and the humanized version of   the antibody were constructed and characterized by indirect ELISA and Western   Blot. They were able to bind to C. burnetii and to inhibit the infection in   mice and in mouse Bone Marrow-Derived Macrophages (BMDM) in vitro. The   humanized version inhibited C. burnetii infection in human macrophages in   vitro. The Fab fragment was able to neutralize virulent C. burnetii resulting   in inhibiting C. burnetii infection in both in vitro and in vivo systems   (US20150087807A1).

Antibody First   Published

Peng et al. Development of a   lipopolysaccharide targeted peptide mimic vaccine against Q fever. J Immunol.   2012 Nov 15; 189(10): 10.4049/jimmunol.1201622. PMID:23053512

Note on publication

The paper describes the generation and   characterization of the antibody.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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