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Anti-Pep27 mAbs

简要描述:

This antibody is specific for the Streptococcus pneumoniae Pep27. The epitope recognized by this antibody is located within the residues 18-27, with key residues crucial for the binding being Y24, R26, and K27, as identified through alanine scanning and further supported by molecular docking analyses. Streptococcus pneumoniae Pep27 is a small, secreted peptide consisting of 27 amino acids initially described as a "death signal peptide".

产品参数:

Cat. No.:MABL-2671

Species:Engineer

Species Reactivity:Streptococcus pneumoniae (S. Pneumoniae)

Type:Recombinate

Application:​IB, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2671

Name

Anti-Pep27 mAbs

Clone No.

AFD- E2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IB, ELISA

Species Reactivity

Streptococcus pneumoniae (S. Pneumoniae)

Basic Information


Specificity

This antibody is specific for the   Streptococcus pneumoniae Pep27. The epitope recognized by this antibody is   located within the residues 18-27, with key residues crucial for the binding   being Y24, R26, and K27, as identified through alanine scanning and further   supported by molecular docking analyses. Streptococcus pneumoniae Pep27 is a   small, secreted peptide consisting of 27 amino acids initially described as a "death signal peptide".

Alternative Name

Pep27 protein

UniProt

B2IMR9

Immunogen

The original antibody was selected from a synthetic   human scFv library encoding HA-tagged scFv clones through five rounds of   biopanning against synthetic and recombinant Pep27.

Application Notes

The dissociation constant (Kd) of the   original human scFv version of this antibody was 1.1 µM as measured in an   ELISA. This antibody specifically detected Pep27 in an immunoblot and in an   environment mimicking in vivo conditions, demonstrated in human serum (Kim et   al. 2018; PMID: 29753735).

Antibody First   Published

Kim et al., Molecular characterization of   single-chain antibody variable fragments (scFv) specific to Pep27 from   Streptococcus pneumoniae. Biochem Biophys Res Commun. 2018 Jun   27;501(3):718-723. doi: 10.1016/j.bbrc.2018.05.054. PMID:29753735

Note on publication

The original publication describes the   development and characterization of two monoclonal scFvs that are specific to   Streptococcus pneumoniae Pep27.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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