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Anti-PD-1 mAbs

简要描述:

This antibody is specific for murine PD-1.

产品参数:

Cat. No.:MABL-2639

Species:Engineer

Species Reactivity:Mouse

Type:Recombinate

Application:depleting, IP, neutralising, ELISA, FC, IHC

详细介绍

Key features and   details


Cat. No.

MABL-2639

Name

Anti-PD-1 mAbs

Clone No.

AFD- J43

From

Recombinant Antibody

Isotype

Engineer antibody

Application

depleting, IP, neutralising, ELISA, FC, IHC

Species Reactivity

Mouse

Basic Information


Specificity

This antibody is specific for murine PD-1.

Alternative Name

CD279; PD1; PD 1; Programmed cell death   protein 1; Programmed cell death 1; pdcd1; Protein PD-1; mPD-1

UniProt

Q02242

Immunogen

This antibody was raised by immunising   Armenian hamsters with B12 cells, a PD-1 cDNA transfectant of BHK cells.

Application Notes

The specificity of this antibody has been   confirmed in ELISA analysis, using PD-1 extracellular domain fusion proteins   (Agata et al, 1996). Additionally, in flow cytometric analysis, this antibody   reacts with PD-1 cDNA-transfected BHK and CHO cells, but not with parental BHK and CHO cells, as well as reacting with lymphocytes from PD-1 cDNA   transgenic mice (Agata et al, 1996). This antibody has been used to   immunoprecipitate PD-1 from lysates of PD-1 cDNA-transfected BHK and CHO   cells (Agata et al, 1996), in flow cytometric quantification of CD4+PD-1+ T   cells in murine spleens (Kasagi et al, 2010), and in immunohistochemical   analysis of acetone-fixed murine spinal cord and brain tissue sections   (Salama et al, 2003). This antibody displays diverse effects in different   mouse models of disease. When administered to NZB/W F1 mice, a model of   lupus-like nephritis, this antibody has been shown to delay the onset of   nephritis and prolong survival, through the depletion of PD-1+ T cells   (Kasagi et al, 2010).

Antibody First   Published

Agata et al. Expression of the PD-1 antigen   on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 1996  May;8(5):765-72. PMID:8671665

Note on publication

Describes the original generation of this antibody, and its use in ELISA, flow cytometry and immunoprecipitation analyses

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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