Anti-PD-1 mAbs

Cat. No.

MABL-2637

Name

Anti-PD-1 mAbs

Clone No.

AFD- Anti-human PD-1 antibody

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, inhibition, ELISA

Species Reactivity

Human

Basic Information

Specificity

The antibody is specific for PD-1. The   antibody binds the extracellular region of the human PD- 1 protein receptor.   PD-1 is a type I membrane protein with 288 amino acids, and is one of the   main known immune checkpoints. PD-1 is expressed in activated T lymphocytes,   and it binds ligands PD-L1 and PD-L2.

Alternative Name

CD279; Programmed cell death protein 1;   PDCD1; PD-1; hPD-1; Human programmed cell death receptor-1

UniProt

Q15116

Immunogen

The original antibody was generated by   immunizing transgenic mice with PD-1.

Application Notes

The specificity of the original format of   the antibody was confirmed by ELISA analysis (EC50 = 76 pM). The antibody   blocked the binding between PD-1 protein and its ligands PD-L1 and PD-L2 by   the receptor ligand binding assay of PD-1 protein. Lymphocyte stimulation   assay detected that PD-1 antibody blocked the binding of PD-1 protein to its   ligands PD-L1 and PD-L2, thereby releasing its inhibition of T lymphocyte   activity (CN106928361A).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.