Key features and details | |
Cat. No. | MABL-2637 |
Name | Anti-PD-1 mAbs |
Clone No. | AFD- Anti-human PD-1 antibody |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, inhibition, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for PD-1. The antibody binds the extracellular region of the human PD- 1 protein receptor. PD-1 is a type I membrane protein with 288 amino acids, and is one of the main known immune checkpoints. PD-1 is expressed in activated T lymphocytes, and it binds ligands PD-L1 and PD-L2. |
Alternative Name | CD279; Programmed cell death protein 1; PDCD1; PD-1; hPD-1; Human programmed cell death receptor-1 |
UniProt | Q15116 |
Immunogen | The original antibody was generated by immunizing transgenic mice with PD-1. |
Application Notes | The specificity of the original format of the antibody was confirmed by ELISA analysis (EC50 = 76 pM). The antibody blocked the binding between PD-1 protein and its ligands PD-L1 and PD-L2 by the receptor ligand binding assay of PD-1 protein. Lymphocyte stimulation assay detected that PD-1 antibody blocked the binding of PD-1 protein to its ligands PD-L1 and PD-L2, thereby releasing its inhibition of T lymphocyte activity (CN106928361A). |
Antibody First Published | |
Note on publication | |
COA Information (For reference only, actual COA shall prevail) | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |