Key features and details | |
Cat. No. | MABL-2620 |
Name | Anti-PCNA mAbs |
Clone No. | AFD- PC10 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, FC, IF, IHC |
Species Reactivity | Insect, S. pombe, Human |
Basic Information | |
Specificity | This antibody binds to PCNA from various vertebrate, invertebrate and fungal species. |
Alternative Name | Proliferating cell nuclear antigen; cyclin or polymerase delta accessory protein |
UniProt | P12004 |
Immunogen | Protein A-PCNA fusion obtained from pC2T. |
Application Notes | PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value. Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
