Anti-MuSK mAbs

Cat. No.

MABL-2425

Name

Anti-MuSK mAbs

Clone No.

AFD- MuSK #13

From

Recombinant Antibody

Isotype

Engineer antibody

Application

in vitro, in vivo

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human MuSK.

Alternative Name

Muscle-specific kinase receptor; Muscle,   skeletal receptor tyrosine- protein kinase; Muscle-specific tyrosine-protein   kinase receptor

UniProt

O15146

Immunogen

This antibody was raised by immunizing mice   with human MuSK.

Application Notes

The original antibody was used in vitro to   test if it could activate its target. It showed to be a potent MuSK   activator. The antibody was also tested in vivo on mice. Here is was shown to   localize to the neuromuscular junctions here it increased innervation. This   antibody did not show any delay in onset of ALS symptoms (Sengupta-Ghosh et   al., 2019; PMID: 30528255).

Antibody First   Published

Sengupta-Ghosh et al. Muscle specific kinase   (MuSK) activation preserves neuromuscular junctions in the diaphragm but is   not sufficient to provide a functional benefit in the SOD1G93A mouse model of   ALS Neurobiol Dis. 2019 Apr:124:340-352. PMID:30528255

Note on publication

In the original paper they treated the SOD1G93A mouse model of ALS with an agonist antibody to muscle specific kinase (MuSK), a receptor tyrosine kinase required for the formation and   maintenance of the neuromuscular junction.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.