Key features and details | |
Cat. No. | MABL-2344 |
Name | Anti-MERS-CoV Spike Protein mAbs |
Clone No. | AFD- D12 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallization, NTRL, ELISA, IF |
Species Reactivity | MERS-CoV |
Basic Information | |
Specificity | This antibody binds to MERS-CoV spike protein receptor binding domain on the S1 protein. It is reported to cross-reacts with MERS-CoV strains England1, Bishan1, England1-D509G, whilst binding to England1-S532P, W535R and E536R is impaired. |
Alternative Name | MERS-RBD; Middle East respiratory syndrome coronavirus spike |
UniProt | |
Immunogen | MERS-CoV (England1 strain) S1 protein. |
Application Notes | This antibody binds to MERS-spike protein receptor binding domain, and has neutralizing effect in an in vitro model and was elicited by a vaccine conferring long-lasting in vivo protection. This antibody does not work by Western Blot. |
Antibody First Published | Wang et al. Evaluation of candidate vaccine approaches for MERS-CoV Nat Commun 6, 7712 (2015) PMID:26218507 |
Note on publication | Describes the generation as well as functional and structural characterization of this antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
