Key features and details | |
Cat. No. | MABL-2085 |
Name | Anti-IL-5 mAbs |
Clone No. | AFD-2E3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralising, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human rIL-5, and does not cross-react with human rIL-1α, rIL-lβ, rIL- 4, rIL-8, rM-CSF, or rTGF-α. |
Alternative Name | interleukin 5; IL5; IL 5; Eosinophil differentiation factor |
UniProt | C9JQP9 |
Immunogen | This antibody was raised by immunising CAF1 mice with human recombinant IL-5. |
Application Notes | This antibody has been show to inhibit the binding of human rIL-5 to the alpha chain of the IL-5 receptor (Ames et al, 1995). This antibody inhibits the proliferation of murine B13 cells in response to human IL-5 (Ames et al, 1995).Neutralising antibodies against IL-5 represent a potential therapeutic strategy for the treatment of eosinophilia. The specificity of this antibody for human IL-5 has been confirmed in ELISA analysis (Ames et al, 1995). |
Antibody First Published | Ames et al. Neutralizing murine monoclonal antibodies to human IL-5 isolated from hybridomas and a filamentous phage Fab display library. J. Immunol. 154 (12), 6355-6364 (1995) PMID:7759873 |
Note on publication | Describes the original generation of this antibody, and its characterisation and use in ELISA. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
