Key features and details | |
Cat. No. | MABL-1926 |
Name | Anti-ICOSL mAbs |
Clone No. | AFD- HK5.3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody specifically binds to mouse ICOSL and competes with binding of ICOS. |
Alternative Name | B7RP-1; B7-related protein 1; ICOS ligand; CD275; LICOS; B7h |
UniProt | Q9JHJ8 |
Immunogen | This antibody was raised by immunizing SD rat with mouse B7h-transfected L cells and fusing immune splenocytes with P3U1 myeloma cells and screened for binding to mouse B7h-transfected NRK cells. |
Application Notes | This antibody has been used to detect murine ICOSL by flow cytometry. It is able to block ICOSL interacting with ICOSL and inhibit T-cell proliferation in a collagen type II (CII)-induced arthritis model. |
Antibody First Published | Iwai et al. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J Immunol. 2002 Oct 15;169(8):4332-9 PMID:12370365 |
Note on publication | Describes the generation and initial characterisation of this antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
